In a meeting with tribal leaders and clerics from a number of Iraqi provinces in Karbala, Sheikh Abdul Mahdi al-Karbalayi stressed that the clergy and the tribes in the western and northern provinces should not allow the terror group to return.
It came after at least four people were killed and 15 others wounded in a car bomb blast in the northern Iraqi town of Qayyara on Tuesday.
A vehicle packed with explosives was parked near a restaurant and a crowded market area in Qayyara, south of the city of Mosul, police said.
No group immediately claimed responsibility but Daesh has been behind such attacks in the past.
Iraq declared victory over Daesh terror group in December, dislodging the militant group from all territories it held after its self-proclaimed “caliphate”, which also composed part of Syria, collapsed earlier in 2017.
The terrorists have since waged a campaign of kidnapping, killing and bomb attacks targeting civilians.